L-Carnitine and Cardiovascular Disease

Hey all,

Hope you got something out of my article on Nutritional Deficiency and Depression last week. I'm aiming for about one article per week, and I really do hope that they'll progressively improve. 

There has been a bit of a fire storm over the internet about a study published in the journal 'Nature' back in 2011. The study suggests that red meat consumption increases risk of cardio vascular disease through the increase of TMAO(Trimethylamine N-Oxide) concentration levels in blood plasma. Chris Kresser has a great breakdown and rebuttal to this study over on his site.  What I would like to cover is L-Carnitine. In the study, L-Carnitine copped a bit of a beating as it was what was used to increase TMAO levels in the mice that were in the study. I'd like to cover some points that show how L-Carnitine actually reduces risk of cardiovascular disease and promotes better health biomarkers.

There are many diseases related to CVD. Some are causes, others are similar in the way that they are a result of a disease. Primarily, you will see a link between patients/ clients that are obese or overweight that have type 2 diabetes. Diabetics have a significantly higher chance for CVD than most healthy people.

In fact, over 50% of all patients with type 2 diabetes die of coronary artery disease

ID-100113152.jpg

L-Carnitine has been used in studies to increase insulin sensitivity and glucose tolerance in patients with type 2 diabetes with staggering results.

L-carnitine derivative that can be administered orally--increased GDR(glucose disposal rate) by an average of 37% (to an average value of 6.72 mg/kg) in individuals whose baseline GDR was [less than or equal to] 7.9 mg/kg. 

Subjects whose baseline GDR was already above 7.9 mg/kg had no effect from the supplement.

A fantastic study conducted in Iran, took 35 patients and over 12 weeks conducted a double blind, placebo controlled trial, looking at the effect of L-Carnitine on plasma glycemic and lipid profile in patients with type 2 diabetes

After 12 weeks of l-carnitine administration, the concentration of fasting blood glucose had significantly decreased from 143±35 to 130±33 mg/dl...

After a 12-week administration of l-carnitine, the concentration of fasting serum Apo B100 increased significantly from 98±18 to 108±22 mg/dl.

There were no statistically significant changes in HbA1c, LDL-C, HDL-C, LP(a), BMI, WHR in the l-carnitine or the placebo group after 6 and 12 weeks.

What these two studies show is that with L-Carnitine supplementation, insulin resistance decreases with minimal to no negative side effects. Lowered insulin resistance means that there should be significantly less inflammation in the body. Reducing risk of CVD.

Looking at insulin resistance we see reduced mitochondrial function. The mitochondria play a vital role in energy regulation as they are responsible for ATP generation, among other things. Mitochondrion dysfunction through oxidative stress is closely associated with CVD

A substantial number of studies suggest that altered levels of oxidative and nitrosoxidative stress within the cardiovascular environment are essential in the development of cardiovascular disease

The above article explains a lot about DNA and RNA mutations that affect mitochondrial function.

mutations that cause defects in mitochondrial protein synthesis

How this relates to oxidative stress and CVD is that it is

It has been shown that CVD patients have increased mtDNA damage when compared with healthy controls in both the heart and the aorta

Which leads me to another article looking into how L-Carnitine protects plasma components against oxidative alterations.

L-Carnitine in supplement form

L-Carnitine in supplement form

The study looks at the antioxidant properties of L-Carnitine

Recent data have indicate that l-carnitine also plays a role in the regulation of gene transcription, inhibits blood platelet aggregation, stimulates erythropoiesis, and acts as a radical scavenger

We see positive results from the in vitro study

The results demonstrated that l-carnitine added to plasma at concentrations of 0.1 to 100 μM inhibits in vitro the oxidation of blood plasma proteins (measured as levels of carbonyl groups and protein thiols) caused by treatment of human plasma with 100 μM ONOO‾.

and recognises that too much antioxidant activity can have a negative affect on the body. It goes on to suggest that higher dosages, those of which are taken daily.

However, supplementation at very high doses (100 μM in our in vitro experiments) of l-carnitine, which is the most popular and favoured supplement among athletes, seems to be less effective.

So what we can see here, is that with responsible supplementation we can have an antioxidant quality from L-Carnitine, again reducing inflammation and risk of CVD.

All of these studies are pointing in the same direction. We see a reduction of inflammation, proper regulation of system functions and an overall reduction in the risk of CVD.

meatnveg.jpg

With a proper nutrient dense diet, we see similar values. Red meats being a key component of such a diet. The mainstream media will always have a reason for us to be afraid of eating red meat. If its not cholesterol its going to be something else. Use your head when shopping for groceries. If its from the ground and raised properly, and for example I mean cows eating grass, not grains and pumped full of hormone. You're probably going to be making the right choice for you and your family. Please just be mindful of what you hear and read, if its sensationalised theres probably something missing from the story.